MOTS-c

Overview

MOTS-c is a 16-amino-acid peptide encoded not in the cell nucleus but in mitochondrial DNA, within the 12S rRNA gene. It belongs to a small family of mitochondrial-derived peptides discovered in the last decade.

In animal studies MOTS-c activates AMPK, a central energy sensor, and has been linked to improved insulin sensitivity and physical capacity, which is why it is often described as an exercise-mimetic in research.

Research areas

• Insulin sensitivity and glucose metabolism
• AMPK signalling and cellular energy balance
• Exercise capacity and ageing models
• Communication between mitochondria and the nucleus

Specifications

Category

Longevity

Compound

Mitochondrial-derived peptide

Structure

16 amino acids

Form

Lyophilised (freeze-dried) powder in sealed vials

Available as

10mg (10 vials) · 40mg (10 vials) · single vial: 10mg

Quality

Third-party tested

Storage and handling

Unopened vials: freezer (−20 °C) for long-term storage, or refrigerator (2–8 °C) for shorter periods. Keep away from light and moisture. After reconstitution, keep refrigerated.